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Flavopiridol (Hydrochloride)

Product Specifications

UNSPSC Description

Flavopiridol Hydrochloride (Alvocidib Hydrochloride) is a broad inhibitor of CDK, competing with ATP to inhibit CDKs including CDK1, CDK2, CDK4 with IC50s of 30, 170, 100 nM, respectively.

Target Antigen

Autophagy; CDK; HIV

Type

Reference compound

Related Pathways

Anti-infection;Autophagy;Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Flavopiridol-Hydrochloride.html

Purity

99.73

Solubility

DMF : 7.69 mg/mL (ultrasonic)|DMSO : �� 20 mg/mL|H2O : ≥ 20 mg/mL,DMF : 7.69 mg/mL (ultrasonic)|DMSO : ≥ 20 mg/mL|H2O : ≥ 20 mg/mL

Smiles

O=C1C2=C(C=C(C([C@]3([H])[C@H](O)CN(C)CC3)=C2OC(C4=CC=CC=C4Cl)=C1)O)O.[H]Cl

Molecular Weight

438.30

References & Citations

[1]Mahoney E, et al. ER stress and autophagy: new discoveries in the mechanism of action and drug resistance of the cyclin-dependent kinase inhibitor flavopiridol.Blood. 2012 Aug 9;120(6):1262-1273.|[2]Keskin H, et al. Complex effects of flavopiridol on the expression of primary response genes. Cell Div. 2012 Mar 29;7:11.|[3]Kim KS, et al.Thio- and oxoflavopiridols, cyclin-dependent kinase 1-selective inhibitors: synthesis and biological effects. J Med Chem. 2000 Nov 2;43(22):4126-34.Cancer Discov. 2021 Oct 6;candisc.1848.2020.|Cell Commun Signal. 2022 Sep 5;20(1):96.|Proc Natl Acad Sci U S A. 2021 Nov 16;118(46):e2115667118.|Research Square Preprint. 2024 May 2.|ACS Chem Biol. 2017 May 19;12(5):1245-1256.|Acta Pharm Sin B. 26 February 2022.|Biochem Biophys Res Commun. 2019 Jun 11;513(4):967-973.|Biomaterials. 2014 Aug;35(24):6585-94. |bioRxiv. 2023 Sep 7.|bioRxiv. 2024 July 27.|bioRxiv. 2024 Mar 17.|bioRxiv. 2024 Sep 29:2024.09.28.615444.|Cancers (Basel). 2022 Mar 19;14(6):1575.|Cell Chem Biol. 2018 Feb 15;25(2):135-142.e5.|Cell Chem Biol. 2019 Aug 15;26(8):1067-1080.e8. |Cell Mol Life Sci. 2020 May 21.|Cell Rep. 2020 Apr 28;31(4):107586.|Cell Syst. 2018 Apr 25;6(4):424-443.e7.|Cell. 2021 Apr 15;184(8):2167-2182.e22.|Clin Cancer Res. 2020 Apr 15;26(8):2011-2021. |EMBO Rep. 2022 Apr 11;e53932.|Free University of Berlin. Gedruckt mit Genehmigung des Fachbereichs Veterinärmedizin. 2021 Mar.|Harvard Medical School LINCS LIBRARY|Int J Biol Sci. 2023 Aug 6;19(13):4123-4138.|iScience. 2024 May 16.|J Med Chem. 2021 Mar 11;64(5):2725-2738.|Molecules. 2023 Mar 4.|Nature. 2024 Apr;628(8007):408-415.|PLoS Genet. 2024 Jun 3;20(6):e1011308.|Purdue University. Department of Chemistry.|Research Square Preprint. 2022 Jan.|Research Square Preprint. 2024 Apr 2.|School of Medicine, Department of Pharmacology. 2020 Jun.|Sci Data. 2024 Sep 19.|Sci Rep. 2015 Dec 1;5:17675. |Sci Rep. 2021 Mar 8;11(1):5374.|Sci Rep. 2024 Oct 31;14(1):26239.|Sci Transl Med. 2018 Jul 18;10(450):eaaq1093.|The University of Chicago. Biological Sciences Division Pritzker School of Medicine. 2022 Aug.|Toxicol Lett. 2024 Sep 12:S0378-4274(24)02025-3.|Turk Neurosurg. 2016;26(6):922-929.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-10006/Flavopiridol-Hydrochloride-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-10006/Flavopiridol-Hydrochloride-SDS-MedChemExpress.pdf

Clinical Information

Phase 2

CAS Number

131740-09-5

Available Sizes

Curated Selection

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