αvβ6-IN-2
αvβ6-IN-2 (compound 20) is a potent and orally active αvβ6 integrin inhibitor with a pIC50 value of 7.8. αvβ6-IN-2 has the potential for the research of idiopathic pulmonary fibrosis[1].
Product Specifications
UNSPSC
12352005
Target
Integrin
Type
Reference compound
Related Pathways
Cytoskeleton
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/αvβ6-in-2.html
Smiles
COC1=CC(C(CC(O)=O)CN2CC(C(F)(CCC3=NC4=C(CCCN4)C=C3)F)C2)=CC=C1F
Molecular Formula
C25H30F3N3O3
Molecular Weight
477.52
References & Citations
[1]Hryczanek HF, et al. Core Modifications of GSK3335103 toward Orally Bioavailable αvβ6 Inhibitors with Improved Synthetic Tractability. J Med Chem. 2024 Oct 17
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
αvβ6
Curated Selection
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