(R) -IHMT-PI3Kδ-372
(R) -IHMT-PI3Kδ-372 (R-18) is a potent and selective PI3Kδ inhibitor with an IC50 of 19 nM. (R) -IHMT-PI3Kδ-372 (R-18) can be used in chronic obstructive pulmonary disease (COPD) research[1].
Product Specifications
CAS Number
[2429889-62-1]
UNSPSC
12352005
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/r-ihmt-pi3kδ-372.html
Purity
99.75
Smiles
CC[C@H](C(N1C2CC2)=NC3=CC=CC(F)=C3C1=O)N4C5=NC=NC(N)=C5C(C6=CC(F)=C(C=C6)OC)=N4
Molecular Formula
C26H23F2N7O2
Molecular Weight
503.50
References & Citations
[1]Li F, et al. Discovery of (S) -2- (1- (4-Amino-3- (3-fluoro-4-methoxyphenyl) -1H-pyrazolo[3,4-d]pyrimidin-1-yl) propyl) -3-cyclopropyl-5-fluoroquinazolin-4 (3H) -one (IHMT-PI3Kδ-372) as a Potent and Selective PI3Kδ Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease. J Med Chem. 2020 Nov 25;63 (22) :13973-13993.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kδ
Available Sizes
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