(R) -IHMT-PI3Kδ-372

(R) -IHMT-PI3Kδ-372 (R-18) is a potent and selective PI3Kδ inhibitor with an IC50 of 19 nM. (R) -IHMT-PI3Kδ-372 (R-18) can be used in chronic obstructive pulmonary disease (COPD) research[1].

Product Specifications

CAS Number

[2429889-62-1]

UNSPSC

12352005

Target

PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/r-ihmt-pi3kδ-372.html

Purity

99.75

Smiles

CC[C@H](C(N1C2CC2)=NC3=CC=CC(F)=C3C1=O)N4C5=NC=NC(N)=C5C(C6=CC(F)=C(C=C6)OC)=N4

Molecular Formula

C26H23F2N7O2

Molecular Weight

503.50

References & Citations

[1]Li F, et al. Discovery of (S) -2- (1- (4-Amino-3- (3-fluoro-4-methoxyphenyl) -1H-pyrazolo[3,4-d]pyrimidin-1-yl) propyl) -3-cyclopropyl-5-fluoroquinazolin-4 (3H) -one (IHMT-PI3Kδ-372) as a Potent and Selective PI3Kδ Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease. J Med Chem. 2020 Nov 25;63 (22) :13973-13993.