GFB-12811
Product Specifications
UNSPSC Description
GFB-12811 is a high selective and orally active CDK5 inhibitor with an IC50 of 2.3 nM. GFB-12811 is highly selective over the other tested kinases (CDK1/2/6/7/9)[1].
Target Antigen
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/gfb-12811.html
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CN1CCC(CC1)[C@@](O)(C2=CC=C3C=NC(NC4=CC(C(F)(F)F)=NC=C4F)=CC3=N2)C
Molecular Weight
449.44
References & Citations
[1]Daniels MH, et al. Discovery and Optimization of Highly Selective Inhibitors of CDK5. J Med Chem. 2022;65(4):3575-3596.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-144117/GFB-12811-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-144117/GFB-12811-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2775311-17-4
Available Sizes
Curated Selection
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