GFB-12811
GFB-12811 is a high selective CDK5 inhibitor with an IC50 of 2.3 nM[1].
Product Specifications
CAS Number
2775311-17-4
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/gfb-12811.html
Purity
98.04
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CN1CCC(CC1)[C@@](O)(C2=CC=C3C=NC(NC4=CC(C(F)(F)F)=NC=C4F)=CC3=N2)C
Molecular Formula
C22H23F4N5O
Molecular Weight
449.44
References & Citations
[1]Daniels MH, et al. Discovery and Optimization of Highly Selective Inhibitors of CDK5. J Med Chem. 2022;65 (4) :3575-3596.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK2; CDK5; CDK6; CDK7; CDK9
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS6308080-01 0.2 mL
HOXD10, CT (HOXD10, HOX4D, HOX4E, Homeobox protein Hox-D10, Homeobox protein Hox-4D, Homeobox protein Hox-4E) (Biotin)
Sign In for Pricing
View Details MBS6308080-02 5x 0.2 mL
HOXD10, CT (HOXD10, HOX4D, HOX4E, Homeobox protein Hox-D10, Homeobox protein Hox-4D, Homeobox protein Hox-4E) (Biotin)
Sign In for Pricing
View Details