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Chrodrimanin B

Chrodrimanin B, a metabolite of a fungal, is a potent, non-open-channel-blocking antagonist on B. mori GABAR RDL with an IC50 of 1.13 nM. Chrodrimanin B attenuates the peak current amplitude of the GABA response of RDL with an IC50 of 1.66 nM. Chrodrimanin B, a meroterpenoid, shows insecticidal activity[1].

Product Specifications

CAS Number

[132196-54-4]

UNSPSC

12352005

Target

GABA Receptor

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/chrodrimanin-b.html

Solubility

10 mM in DMSO

Smiles

C[C@@]([C@@](C(C)1C)([H])C[C@@H]2O)(C=CC1=O)[C@@](CC3=C([C@H]([C@H]4C)OC(C)=O)C(C(O4)=O)=C5O)([H])[C@]2(OC3=C5)C

Molecular Formula

C27H32O8

Molecular Weight

484.54

References & Citations

[1]Yan Xu, et al. Meroterpenoid Chrodrimanins Are Selective and Potent Blockers of Insect GABA-Gated Chloride Channels. PLoS One. 2015 Apr 22;10 (4) :e0122629.

Shipping Conditions

Room temperature

Scientific Category

Natural Products

Clinical Information

No Development Reported

Curated Selection

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