CK2α-IN-1

CK2α-IN-1 (compound 2) is a selective CK2α inhibitor (IC50=7.0 µM; Ki=1.6 µM) that exhibits a non-ATP-competitive mode of action. CK2α-IN-1 exhibits good potential for anticancer studies[1].

Product Specifications

CAS Number

[443747-52-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Casein Kinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ck2α-in-1.html

Purity

98.34

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=CC(NC2=NC(C3=CC([N+]([O-])=O)=CC=C3)=CS2)=CC=C1)O

Molecular Formula

C16H11N3O4S

Molecular Weight

341.34

Precautions

H302, H315, H319

References & Citations

[1]Bestgen B, et al. 2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 1. Identification of an Allosteric Binding Site. J Med Chem. 2019 Feb 28;62 (4) :1803-1816.