VEGFR-2-IN-43
VEGFR-2-IN-43 (compound 16) is an orally active inhibitor of VEGFR2, with an IC50 of 39.91 μM. VEGFR-2-IN-43 can be used for wet age-related macular degeneration (w-AMD) disease research[1].
Product Specifications
UNSPSC
12352005
Target
VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/vegfr-2-in-43.html
Solubility
10 mM in DMSO
Smiles
CCO[C@@H]1CN(C[C@H]1NC(C2=C(NC(/C=C3C(NC4=CC=C(C=C4\3)F)=O)=C2C)C)=O)C(CO)=O
Molecular Formula
C24H27FN4O5
Molecular Weight
470.49
References & Citations
[1]Xiu X, et al. Potential oral VEGFR2 inhibitors: Treatment of wet age-related macular degeneration. Bioorg Chem. 2024 Mar;144:107110.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
VEGFR2/KDR/Flk-1
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