SPDZi1
Product Specifications
UNSPSC Description
SPDZi1 is a potent and selective syntenin inhibitor that binds to PDZ1 and PDZ2 domains of syntenin. SPDZi1 binds to the syntenin PDZ tandem (STNPDZ) with a Kd of 3.6 μM. SPDZi1 suppresses glioblastoma and reduces the activation of NF-κB, a downstream effector of syntenin[1].
Target Antigen
NF-κB
Type
Reference compound
Related Pathways
NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/spdzi1.html
Smiles
O=C(N[C@@H](CC(N1)=NC=CC1=O)C(O)=O)OCC(C2=C3C=CC=C2)C4=C3C=CC=C4
Molecular Weight
405.40
References & Citations
[1]Yunseok Heo, et al. Discovery of a potent inhibitor that suppresses glioblastoma by dual targeting of both syntenin PDZ domains. bioRxiv preprint. April 04, 2024.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162510/SPDZi1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162510/
Clinical Information
No Development Reported
Curated Selection
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