SPDZi1
SPDZi1 is a potent and selective syntenin inhibitor that binds to PDZ1 and PDZ2 domains of syntenin. SPDZi1 binds to the syntenin PDZ tandem (STNPDZ) with a Kd of 3.6 μM. SPDZi1 suppresses glioblastoma and reduces the activation of NF-κB, a downstream effector of syntenin[1].
Product Specifications
UNSPSC
12352005
Target
NF-κB
Type
Reference compound
Related Pathways
NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/spdzi1.html
Smiles
O=C(N[C@@H](CC(N1)=NC=CC1=O)C(O)=O)OCC(C2=C3C=CC=C2)C4=C3C=CC=C4
Molecular Formula
C22H19N3O5
Molecular Weight
405.40
References & Citations
[1]Yunseok Heo, et al. Discovery of a potent inhibitor that suppresses glioblastoma by dual targeting of both syntenin PDZ domains. bioRxiv preprint. April 04, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LV758912 1.0 µg DNA
CECR5-AS1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)
Sign In for Pricing
View Details 
