NMS-P953

NMS-P953 (compound 28) is an orally active JAK2 inhibitor (IC50=0.008 μM) with antitumor activity[1].

Product Specifications

CAS Number

[1403679-33-3]

UNSPSC

12352005

Target

JAK

Type

Reference compound

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nms-p953.html

Smiles

O=C(C1=C(C2=CC(C(F)(F)F)=CC=C2Cl)NC(C3=NC(N)=NC=C3)=C1)N

Molecular Formula

C16H11ClF3N5O

Molecular Weight

381.74

References & Citations

[1]Brasca M G, et al. Pyrrole-3-carboxamides as potent and selective JAK2 inhibitors[J]. Bioorganic & Medicinal Chemistry, 2014, 22 (17) : 4998-5012.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

JAK2

Curated Selection

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