CD38 inhibitor 3
CD38 inhibitor 3 (compound 1) is the orally active inhibitor for CD38 (IC50=11 nM) . CD38 inhibitor 3 increases intracellular NAD+ levels, activates the Nrf2 signaling pathway, and promotes mitochondrial biogenesis. CD38 inhibitor 3 improves muscle function[1].
Product Specifications
CAS Number
[2857868-82-5]
UNSPSC
12352005
Target
CD38
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/cd38-inhibitor-3.html
Purity
99.16
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=NC(N2C=NC=C2)=NC(C(F)(F)F)=C1)NC3=CN=C(OCCOC)N=C3
Molecular Formula
C16H14F3N7O3
Molecular Weight
409.32
References & Citations
[1]Li Y, et al. Discovery of a First-in-Class CD38 Inhibitor for the Treatment of Mitochondrial Myopathy. J Med Chem. 2023 Sep 11.. .
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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