CD38 inhibitor 3
Product Specifications
UNSPSC Description
CD38 inhibitor 3 (compound 1) is a potent CD38 inhibitor (IC50=11 nM). CD38 inhibitor 3 can promote mitochondrial biogenesis, reduce lactate levels, and increase NAD+ content and Nrf2 expression. In a model of mitochondrial myopathy, CD38 inhibitor 3 increases muscle contraction/development and improves exercise tolerance in Pus1-/- mice[1].
Target Antigen
CD38
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/cd38-inhibitor-3.html
Solubility
DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C(C1=NC(N2C=NC=C2)=NC(C(F)(F)F)=C1)NC3=CN=C(OCCOC)N=C3
Molecular Weight
409.32
References & Citations
[1]Li Y, et al. Discovery of a First-in-Class CD38 Inhibitor for the Treatment of Mitochondrial Myopathy. J Med Chem. 2023 Sep 11.. .
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-156120/CD38-inhibitor-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-156120/CD38-inhibitor-3-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2857868-82-5
Available Sizes
Curated Selection
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