CCB02
CCB02 is a selective CPAP-tubulin interaction inhibitor, binding to tubulin and competing for the CPAP binding site of β-tubulin, with an IC50 of 689 nM, and shows potent anti-tumor activity. CCB02 shows no inhibition on the cell cycle- and centrosome-related kinases, or the phosphorylation status of Aurora A, Plk1, Plk2, CDK2, and CHK1[1].
Product Specifications
CAS Number
2100864-57-9
Product Name Alternative
(-)-Pindolol; (S)-(-)-Pindolol; S-Pindolol,ONO1109,ONO1101 (hydrochloride)
UNSPSC
12352005
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CCB02.html
Purity
99.93
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
N#CC1=C(OC)N=CC2=CC3=CC=CC=C3N=C12
Molecular Formula
C14H9N3O
Molecular Weight
235.24
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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