DCeMM3
DCeMM3 (Compound 3) is a molecular glue degrader. dCeMM3 induces ubiquitination and degradation of cyclin K by prompting an interaction of CDK12-cyclin K with a CRL4B ligase complex[1].
Product Specifications
CAS Number
311787-85-6
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
CDK; Molecular Glues
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dcemm3.html
Concentration
10mM
Purity
98.19
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(NC1=NC=C(Cl)C=C1)CSC2=NC3=CC=CC=C3N2
Molecular Formula
C14H11ClN4OS
Molecular Weight
318.78
Precautions
H315, H319, H320
References & Citations
[1]Mayor-Ruiz C, et al. Rational discovery of molecular glue degraders via scalable chemical profiling [published correction appears in Nat Chem Biol. 2021 Mar;17 (3) :361]. Nat Chem Biol. 2020;16 (11) :1199-1207.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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