DNA Gyrase/DHFR-IN-1
DNA Gyrase/DHFR-IN-1 is a dual inhibitor of bacterial DNA gyrase and DHFR, with IC50s of 182 μM and 3.90 μM for E. coli DNA gyrase and DHFR respectively. DNA Gyrase/DHFR-IN-1 has bactericidal and antifungal activity[1].
Product Specifications
UNSPSC
12352005
Target
Bacterial; Dihydrofolate reductase (DHFR) ; Fungal
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/dna-gyrase-dhfr-in-1.html
Smiles
CC1=CC=C(C2=CC(C3=CC=C(OC)C=C3)=NC4=NC(C5=CC=CC=C5)=NN24)C=C1
Molecular Formula
C25H20N4O
Molecular Weight
392.45
References & Citations
[1]Lamya H. Al-Wahaibi, et al. Synthesis and Antimicrobial Evaluation of New 1,2,4-Triazolo[1,5-a]pyrimidine-Based Derivatives as Dual Inhibitors of Bacterial DNA Gyrase and DHFR.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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