2-MPPA
2-MPPA (GPI-5693) is an orally active and selective glutamate carboxypeptidase II (GCP II; PSMA) inhibitor with an IC50 of 90 nM[1][2].
Product Specifications
CAS Number
254737-29-6
Product Name Alternative
GPI-5693
UNSPSC
12352211
Target
Carboxypeptidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/2-mppa.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)C(CCCS)CCC(O)=O
Molecular Formula
C8H14O4S
Molecular Weight
206.26
References & Citations
[1]Takatsu Y, et al. Orally active glutamate carboxypeptidase II inhibitor 2-MPPA attenuates dizocilpine-induced prepulse inhibition deficits in mice. Brain Res. 2011 Jan 31;1371:82-6. |[2]She Y, et al. 2-MPPA, a selective inhibitor of PSMA, delays prostate cancer growth and attenuates taxol-induced neuropathy in mice. Journal of Clinical Oncology, 2005, 23 (16_suppl) : 8054-8054.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
38622062 1.0 µg DNA
RBM26 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)
Sign In for Pricing
View Details MBS2103214-01 5x 96 Tests
Human Diacylglycerol Kinase Zeta (DGKz) Antibody Pair Kit (with Standard)
Sign In for Pricing
View Details MBS2103214-02 5x 96 Tests + MBS2090685 (Ab Pairs Support Pack 1,5x 96 Tests)
Human Diacylglycerol Kinase Zeta (DGKz) Antibody Pair Kit (with Standard)
Sign In for Pricing
View Details