SIA Crosslinker
SIA Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].
Product Specifications
CAS Number
39028-27-8
Product Name Alternative
Iodoacetic acid N-hydroxysuccinimide ester; N-Succinimidyl Iodoacetate
UNSPSC
12352203
Hazard Statement
H315, H319, H335
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sia-crosslinker.html
Purity
98.0
Solubility
DMF : ≥ 100 mg/mL|DMSO : ≥ 100 mg/mL
Smiles
O=C(ON1C(CCC1=O)=O)CI
Molecular Formula
C6H6INO4
Molecular Weight
283.02
Precautions
H315, H319, H335
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Non-cleavable Linker
Available Sizes
Frequently Asked Questions
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