YM440

YM440 is an orally active oxadiazolidinedione analog. YM440 ameliorates hyperglycemia without changing PPARy activity, adipocyte differentiation, or fat weight. YM440 is used in the study for non-insulin-dependent diabetes mellitus (NIDDM) [1].

Product Specifications

CAS Number

[163300-58-1]

UNSPSC

12352005

Target

PPAR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/ym440.html

Smiles

O=C(NC1=O)ON1CC2=CC=C(C=C2)OC/C=C\COC3=CC=C(C=C3)CN4OC(NC4=O)=O

Molecular Formula

C22H20N4O8

Molecular Weight

468.42

References & Citations

[1]A Shimaya, et al. The novel hypoglycemic agent YM440 normalizes hyperglycemia without changing body fat weight in diabetic db/db mice. Metabolism. 2000 Mar;49 (3) :411-7.|[2]Eiji Kurosaki, et al. Differential effects of YM440 a hypoglycemic agent on binding to a peroxisome proliferator-activated receptor gamma and its transactivation. Biochem Pharmacol. 2003 Mar 1;65 (5) :795-805.