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Brompheniramine (Standard)

Brompheniramine (Standard) is the analytical standard of Brompheniramine. This product is intended for research and analytical applications. Brompheniramine ((±) -Brompheniramine) is a potent and orally active antihistamine of the alkylamine class. Brompheniramine is a selective histamine H1 receptor antagonist with a Kd of 6.06 nM. Brompheniramine can block the hERG channels, calcium channels, and sodium channels with IC50s of 0.90 μM, 16.12 μM and 21.26 μM, respectively. Brompheniramine has anticholinergic, antidepressant and anesthetic properties and can be used for allergic rhinitis research[1][2][3][4].

Product Specifications

CAS Number

86-22-6

Product Name Alternative

(±) -Brompheniramine (Standard)

UNSPSC

12352005

Target

Calcium Channel; Histamine Receptor; mAChR; Potassium Channel; Reference Standards; Sodium Channel

Type

Reference Standards

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Field of Research

Endocrinology; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/brompheniramine-standard.html

Smiles

CN(C)CCC(C1=CC=C(Br)C=C1)C2=CC=CC=N2

Molecular Formula

C16H19BrN2

Molecular Weight

319.24

References & Citations

[1]Chong-Chi Chiu, et al. Subcutaneous brompheniramine for cutaneous analgesia in rats. Eur J Pharmacol. 2019 Oct 5;860:172544.|[2]B Cusack, et al. Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl) . 1994 May;114 (4) :559-65.|[3]Shin WH, Kim KS, Kim EJ. Electrophysiological effects of brompheniramine on cardiac ion channels and action potential. Pharmacol Res. 2006 Dec;54 (6) :414-20.|[4]Yasuda SU, Yasuda RP. Affinities of brompheniramine, chlorpheniramine, and terfenadine at the five human muscarinic cholinergic receptor subtypes. Pharmacotherapy. 1999 Apr;19 (4) :447-51.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Frequently Asked Questions

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