Cyclo (Gly-Arg-Gly-Asp-Ser-Pro)

Cyclo (Gly-Arg-Gly-Asp-Ser-Pro) (c (GRGDSP) ) is an RGD-containing inhibitory peptide. Cyclo (Gly-Arg-Gly-Asp-Ser-Pro) is a synthetic α5β1 integrin ligand that competitively inhibits the binding of invasin (Inv) to α5β1 integrin expressed on Caco-2 cells[1].

Product Specifications

CAS Number

[135432-37-0]

Product Name Alternative

C (GRGDSP)

UNSPSC

12352209

Target

Integrin

Type

Peptides

Related Pathways

Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cyclo-gly-arg-gly-asp-ser-pro.html

Purity

98.11

Solubility

H2O : ≥ 100 mg/mL

Smiles

O=C1N2[C@@](C(NCC(N[C@H](C(NCC(N[C@H](C(N[C@H]1CO)=O)CC(O)=O)=O)=O)CCCNC(N)=N)=O)=O)([H])CCC2

Molecular Formula

C22H35N9O9

Molecular Weight

569.57

References & Citations

[1]Kumagai H, et al. Effect of cyclic RGD peptide on cell adhesion and tumor metastasis. Biochem Biophys Res Commun. 1991 May 31;177 (1) :74-82.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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