Beaucage reagent

Beaucage reagent is found to be potent in causing DNA cleavage[1][2][3].

Product Specifications

CAS Number

[66304-01-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Beaucage-reagent.html

Purity

98.0

Solubility

DMSO : ≥ 100 mg/mL|H2O : 0.14 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=CC=C12)SS2(=O)=O

Molecular Formula

C7H4O3S2

Molecular Weight

200.24

Precautions

H302, H315, H319, H335

References & Citations

[1]Zheng J, et al. Thiol-dependent DNA cleavage by aminomethylated Beaucage's reagent. Org Biomol Chem. 2010 Mar 21;8 (6) :1293-5.|[2]C. F. H. Allen, et al. Working with Hazardous Chemicals. Organic Syntheses, Coll. Vol. 2, 1943, 580.|[3] Stec W J, et al. Bis (O, O-diisopropoxy phosphinothioyl) disulfide-a highly efficient sulfurizing reagent for cost-effective synthesis of oligo (nucleoside phosphorothioate) s[J]. Tetrahedron letters, 1993, 34 (33) : 5317-5320.