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FX-11

Product Specifications

UNSPSC Description

FX-11 is a potent, selective, reversible and competitive lactate dehydrogenase A (LDHA) inhibitor, with a Ki of 8 μM. FX-11 reduces ATP levels and induces oxidative stress, ROS production and cell death. FX-11 shows antitumor activity in lymphoma and pancreatic cancer xenografts[1][2][3].

Target Antigen

Apoptosis; Lactate Dehydrogenase; Reactive Oxygen Species

Type

Reference compound

Related Pathways

Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/FX-11.html

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(C1=C2C=C(CC3=CC=CC=C3)C(C)=CC2=C(CCC)C(O)=C1O)O

Molecular Weight

350.41

References & Citations

[1]EC Calvaresi. Small molecule inhibitors of lactate dehydrogenase a as an anticancer strategy. 2014.|[2]Le A, et, al. Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2037-42.|[3]Mohammad GH, et al. Targeting Pyruvate Kinase M2 and Lactate Dehydrogenase A Is an Effective Combination Strategy for the Treatment of Pancreatic Cancer. Cancers (Basel). 2019 Sep 16;11(9):1372.

Shipping Conditions

Blue Ice

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-16214/FX-11-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-16214/FX-11-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

213971-34-7

Available Sizes

Curated Selection

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