FX-11
FX-11 is a potent, selective, reversible and competitive lactate dehydrogenase A (LDHA) inhibitor, with a Ki of 8 μM. FX-11 reduces ATP levels and induces oxidative stress, ROS production and cell death. FX-11 shows antitumor activity in lymphoma and pancreatic cancer xenografts[1][2][3].
Product Specifications
CAS Number
213971-34-7
Product Name Alternative
LDHA Inhibitor FX11
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Apoptosis; Lactate Dehydrogenase; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/FX-11.html
Purity
99.21
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(C1=C2C=C(CC3=CC=CC=C3)C(C)=CC2=C(CCC)C(O)=C1O)O
Molecular Formula
C22H22O4
Molecular Weight
350.41
Precautions
H302, H315, H319
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
LDHA
Available Sizes
Frequently Asked Questions
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