ID-8

ID-8 is an inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) . ID-8 sustains embryonic stem cell (ESC) self-renewal and pluripotency. ID-8 enhances Wnt-mediated hESC survival and proliferation via inhibition of DYRKs[1][2].

Product Specifications

CAS Number

147591-46-6

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

DYRK

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ID-8.html

Purity

99.92

Solubility

DMSO : ≥ 47 mg/mL

Smiles

OC1=CC2=C(C=C1)C([N+]([O-])=O)=C(C)N2C3=CC=C(OC)C=C3

Molecular Formula

C16H14N2O4

Molecular Weight

298.29

Precautions

H302, H315, H319, H335

References & Citations

[1]Hasegawa, K., et al., Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion. Stem Cells Transl Med, 2012. 1 (1) : p. 18-28.|[2]Miyabayashi, T., et al., Indole derivatives sustain embryonic stem cell self-renewal in long-term culture. Biosci Biotechnol Biochem, 2008. 72 (5) : p. 1242-8.