Human IL-39 Protein, Fc Tag (MALS verified)

Interleukin 39 (IL-39) is a new member of the IL-12 family and is composed of IL-23p19 and Ebi3 subunits.The two subunits, IL-23p19 and Ebi3, are shared with IL-23 and IL-27/IL-35. IL-23p19 is a four-helix bun dle and has homology with IL-6 and granulocyte colony stimulating factor. Ebi3 was first identified in B lympho cytes infected with EB virus. Some studies have reported that The combination of IL-23R and gp130 forms the IL-39 receptor. At present, a research on IL-39 is still in its initial stage, and many issues have not been solved.

Product Specifications

Background

Specifications

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 69.4 kDa. The protein migrates as 65-70 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Accession Number

Q14213-1 (IL-27 beta) & Q9NPF7-1 (IL-23 alpha)

Expression Region

Arg 21 - Lys 229 & Arg 20 - Pro 189

Host

HEK293

Target

IL-39

Conjugation

Unconjugated

Tag

C-Fc

Source

Human

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Endotoxin

1.0 EU per μg

Purity

95%

Bioactivity

Immobilized Human IL-39, Fc Tag (Cat. No. IL9-H5259) at 1 μg/mL (100 μL/well) can bind Anti-IL23A MAb with a linear range of 0.02-0.5 μg/mL (QC tested).