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Mefluleucine

Mefluleucine (NV-5138), a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. Mefluleucine is used for antidepressant studies[1][2].

Product Specifications

Product Name Alternative

NV-5138

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

MTOR

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nv-5138.html

Purity

98.0

Solubility

DMSO : 10 mg/mL (ultrasonic)

Smiles

N[C@@H](CC(C)(C(F)F)C)C(O)=O

Molecular Formula

C7H13F2NO2

Molecular Weight

181.18

Precautions

H315, H319, H335

References & Citations

[1]Sengupta S, et al. Discovery of NV-5138, the first selective Brain mTORC1 activator. Sci Rep. 2019 Mar 11;9 (1) :4107.|[2]Kato T, et al. Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation. J Clin Invest. 2019 Apr 16;129 (6) :2542-2554.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-114384/NV-5138-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-114384/Mefluleucine-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

Phase 2

Citation 01

BioRxiv. 2025 Jul 21.|Cell Metab. 2024 Jun 18:S1550-4131 (24) 00189-X.|Mol Immunol. 2025 Nov 28:189:1-12.|Nature. 2025 Feb;638 (8049) :172-181.|bioRxiv. 2023 Apr 24.|biorxiv. 2024 May 27.|McGill University. 2023 Jul 5.|Neuron. 2023 Oct 4;111 (19) :3028-3040.e6.

CAS Number

[2095886-80-7]

Available Sizes

Curated Selection

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