Mefluleucine
Mefluleucine (NV-5138), a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. Mefluleucine is used for antidepressant studies[1][2].
Product Specifications
CAS Number
2095886-80-7
Product Name Alternative
NV-5138
UNSPSC
12352211
Hazard Statement
H315, H319, H335
Target
MTOR
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nv-5138.html
Purity
98.0
Solubility
DMSO : 10 mg/mL (ultrasonic)
Smiles
N[C@@H](CC(C)(C(F)F)C)C(O)=O
Molecular Formula
C7H13F2NO2
Molecular Weight
181.18
Precautions
H315, H319, H335
References & Citations
[1]Sengupta S, et al. Discovery of NV-5138, the first selective Brain mTORC1 activator. Sci Rep. 2019 Mar 11;9 (1) :4107.|[2]Kato T, et al. Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation. J Clin Invest. 2019 Apr 16;129 (6) :2542-2554.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Citation 01
BioRxiv. 2025 Jul 21.|Cell Metab. 2024 Jun 18:S1550-4131 (24) 00189-X.|Mol Immunol. 2025 Nov 28:189:1-12.|Nature. 2025 Feb;638 (8049) :172-181.|bioRxiv. 2023 Apr 24.|biorxiv. 2024 May 27.|McGill University. 2023 Jul 5.|Neuron. 2023 Oct 4;111 (19) :3028-3040.e6.
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