Mefluleucine
Mefluleucine (NV-5138), a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. Mefluleucine is used for antidepressant studies[1][2].
Product Specifications
CAS Number
2095886-80-7
Product Name Alternative
NV-5138
UNSPSC
12352211
Hazard Statement
H315, H319, H335
Target
MTOR
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nv-5138.html
Purity
98.0
Solubility
DMSO : 10 mg/mL (ultrasonic)
Smiles
N[C@@H](CC(C)(C(F)F)C)C(O)=O
Molecular Formula
C7H13F2NO2
Molecular Weight
181.18
Precautions
H315, H319, H335
References & Citations
[1]Sengupta S, et al. Discovery of NV-5138, the first selective Brain mTORC1 activator. Sci Rep. 2019 Mar 11;9 (1) :4107.|[2]Kato T, et al. Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation. J Clin Invest. 2019 Apr 16;129 (6) :2542-2554.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Citation 01
BioRxiv. 2025 Jul 21.|Cell Metab. 2024 Jun 18:S1550-4131 (24) 00189-X.|Mol Immunol. 2025 Nov 28:189:1-12.|Nature. 2025 Feb;638 (8049) :172-181.|bioRxiv. 2023 Apr 24.|biorxiv. 2024 May 27.|McGill University. 2023 Jul 5.|Neuron. 2023 Oct 4;111 (19) :3028-3040.e6.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS9354760 Inquire
Pigeon Transcription Factor IIIB 50kDa Subunit (BRF2) ELISA Kit
Sign In for Pricing
View Details