Mefluleucine

Mefluleucine (NV-5138), a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. Mefluleucine is used for antidepressant studies[1][2].

Product Specifications

CAS Number

[2095886-80-7]

Product Name Alternative

NV-5138

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

MTOR

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nv-5138.html

Purity

98.0

Solubility

DMSO : 10 mg/mL (ultrasonic)

Smiles

N[C@@H](CC(C)(C(F)F)C)C(O)=O

Molecular Formula

C7H13F2NO2

Molecular Weight

181.18

Precautions

H315, H319, H335

References & Citations

[1]Sengupta S, et al. Discovery of NV-5138, the first selective Brain mTORC1 activator. Sci Rep. 2019 Mar 11;9 (1) :4107.|[2]Kato T, et al. Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation. J Clin Invest. 2019 Apr 16;129 (6) :2542-2554.