QL47

QL47, a broad-spectrum antiviral agent, inhibits dengue virus and other RNA viruses. QL47 selectively inhibits eukaryotic translation. QL47 is a potent covalent inhibitor of BTK with an IC50 of 7 nM[1][2][3].

Product Specifications

CAS Number

[1469988-75-7]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Btk; Dengue Virus; Flavivirus

Type

Reference compound

Related Pathways

Anti-infection; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/QL47.html

Purity

99.50

Smiles

O=C1N(C2=C(C=C1)C=NC3=CC=C(C4=CN(C)N=C4)C=C32)C5=CC=C(CC6)C(N6C(C=C)=O)=C5

Molecular Formula

C27H21N5O2

Molecular Weight

447.49

Precautions

H315, H319, H335

References & Citations

[1]Liang Y, et al. Structure-Activity Relationship Study of QL47: A Broad-Spectrum Antiviral Agent. ACS Med Chem Lett. 2017;8 (3) :344-349. Published 2017 Feb 3.|[2]de Wispelaere M, et al. A broad-spectrum antiviral molecule, QL47, selectively inhibits eukaryotic translation. J Biol Chem. 2020;295 (6) :1694-1703.|[3]Wu H, et al. Discovery of a potent, covalent BTK inhibitor for B-cell lymphoma. ACS Chem Biol. 2014;9 (5) :1086-1091.