Antitumor agent-127

Antitumor agent-127 (compound 1) is a parent macrocyclic peptide. Antitumor agent-127 displays nanomolar cell-based binding to ROR1 and relatively good internalization in 786-O and MDA-MB-231 tumor cell lines[1].

Product Specifications

CAS Number

[9007-83-4]

UNSPSC

12352209

Target

ROR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/antitumor-agent-127.html

Purity

99.09

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N[C@H](C(NCC(N)=O)=O)CSCC(N[C@H](C(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CC2=CC=C(O)C=C2)C(N[C@H](C(NCC(N[C@@H](CC3=CNC4=C3C=CC=C4)C(N[C@H]5CC6=CC=C(O)C=C6)=O)=O)=O)CO)=O)=O)C(C)C)=O)=O)=O)CC7=CC=CC=C7)=O)[C@H](CC(C)C)NC([C@H](CC8=CC=CC=C8)N(C)C5=O)=O

Molecular Formula

C86H107N15O18S

Molecular Weight

1670.92

References & Citations

[1]Qiao JX, et al. Exploration of macrocyclic peptide binders to the extracellular CRD domain of human receptor tyrosine kinase-like orphan receptor 1 (ROR1) . Bioorg Med Chem Lett. 2023 Dec 13;98:129589.