(E) -AG 99
(E) -AG 99 ((E) -Tyrphostin 46) is a potent EGFR inhibitor[1].
Product Specifications
CAS Number
122520-85-8
Product Name Alternative
(E) -Tyrphostin 46; (E) -Tyrphostin AG 99
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/_E_-AG_99.html
Purity
98.36
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(N)/C(C#N)=C/C1=CC=C(O)C(O)=C1
Molecular Formula
C10H8N2O3
Molecular Weight
204.19
Precautions
H302, H315, H319, H335
References & Citations
[1]Yamamoto N, et al. Tyrosine phosphorylation of p145met mediated by EGFR and Src is required for serum-independent survival of human bladder carcinoma cells. J Cell Sci. 2006 Nov 15;119 (Pt 22) :4623-33.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1
Available Sizes
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