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GalNAc unconjugated/naked Fitusiran (sodium)

Selected Variant

HY-150224-01

Size: 1 mg

GalNAc unconjugated/naked Fitusiran (sodium), an small interfering RNA without GalNAc conjugation, specifically targets antithrombin (AT) messenger RNA to lower production of AT in the liver. Fitusiran increases thrombin generation and has the potential for the research of the hemophilia[1].

Product Specifications

UNSPSC

12352208

Target

Factor Xa; Small Interfering RNA (siRNA)

Type

Oligonucleotides

Related Pathways

Epigenetics; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/galnac-unconjugated-naked-fitusiran.html

Purity

98.12

Solubility

10 mM in H2O

Smiles

[GalNAcunconjugated/nakedFitusiran(sodium)]

Molecular Weight

14459.60

References & Citations

[1]Pasi KJ, et al. Targeting of antithrombin in hemophilia A or B with investigational siRNA therapeutic fitusiran-Results of the phase 1 inhibitor cohort. J Thromb Haemost. 2021;19 (6) :1436-1446.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Oligonucleotides

Clinical Information

No Development Reported

Available Sizes

Price

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