IL-17RD, Human (HEK293, His)

Product Specifications

UNSPSC Description

Interleukin-17 receptor D (IL-17RD) also known as Sef (similar expression to fibroblast growth factor), is a type I transmembrane protein that can regulate several signaling pathways. Within the cell, IL-17RD expression has been localized mainly to the plasma membrane. IL-17RD is a feedback inhibitor of fibroblast growth factor (FGF) signaling[1]. IL-17RD Protein, Human (HEK293, His) is produced in HEK293 cells with six C-Terminal His-tags.

Type

Recombinant Proteins

Assay Protocol

https://www.medchemexpress.com/cytokines/il-17rd-protein-human-283a-a-hek293-his.html

Smiles

CLNGSQLAVA AGGSGRARGA DTCGWRGVGP ASRNSGLYNI TFKYDNCTTY LNPVGKHVIA DAQNITISQY ACHDQVAVTI LWSPGALGIE FLKGFRVILE ELKSEGRQCQ QLILKDPKQL NSSFKRTGME SQPFLNMKFE TDYFVKVVPF PSIKNESNYH PFFFRTRACD LLLQPDNLAC KPFWKPRNLN ISQHGSDMQV SFDHAPHNFG FRFFYLHYKL KHEGPFKRKT CKQEQTTETT SCLLQNVSPG DYIIELVDDT NTTRKVMHYA LKPVHSPWAG PIR

Molecular Weight

45-65 kDa

References & Citations

[1]Shivangi Pande, et al. Interleukin-17 receptor D (Sef) is a multi-functional regulator of cell signaling. Cell Commun Signal. 2021 Jan 12;19(1):6.|[2]Mark Mellett, et al. Orphan receptor IL-17RD regulates Toll-like receptor signalling via SEFIR/TIR interactions. Nat Commun. 2015 Mar 26;6:6669.|[3]Sihan Liu, et al. A shedding soluble form of interleukin-17 receptor D exacerbates collagen-induced arthritis through facilitating TNF-α-dependent receptor clustering. Cell Mol Immunol. 2021 Aug;18(8):1883-1895.