Urolithin A

Mitophagy inducer

Product Specifications

Background

Urolithin A (UA) is a microbial metabolite of dietary ellagitannins produced in the gut (1). It has been shown to induce mitophagy and prolong lifespan in C. elegans and increase muscle function in rodents (2). It promotes mitophagy and suppresses NLRP3 inflammasome activation in LPS-induced BV2 microglial cells and in an MPTP-induced Parkinson’s disease model (3). The pro-mitophagy activity of Urolitin A may be beneficial in Alzheimer’s disease (4). Ex vivo UA-treated T cells display improved anti-tumor function (5).

Product Name Alternative

3,8-Dihydroxy-6H-dibenzo[b,d]pyran-6-one; or 2',7-Dihydroxy-3,4-benzocoumarin

UNSPSC

41116105

Source

Synthetic

Purity

>98% (HPLC); NMR (Conforms)

Weight

0.005

Format

Pale-yellow powder

Solubility

May be dissolved in DMSO (50 mg/ml)

Molecular Formula

C13H8O4

Molecular Weight

228.2

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1.Gonzalez-Barrio R., et al. (2011) J. Agric. Food. Chem. 59:1152 2.Ryu D., et al. 2016 Nat. Med. 22:879 3.Qiu J., et al. 2022 Neuropharmacology 207:108963 4.Jayatunga D.P.W., et al. 2021 Nutrients. 13:3744 5.Denk D., et al. 2022 Immunity. 55:2059