ABT-737-d8
ABT 737-d8 is the deuterium labeled ABT-737. ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-xL and Bcl-w inhibitor with EC50s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 induces autophagy and has the potential for acute myeloid leukemia (AML) research[1][2][3].
Product Specifications
CAS Number
1217686-68-4
UNSPSC
12352005
Target
Biochemical Assay Reagents
Type
Isotope-Labeled Compounds
Related Pathways
Others
Field of Research
Cancer
Purity
99.11
Solubility
10 mM in DMSO|DMSO : 50mg/mL (ultrasonic)
Smiles
ClC(C=C1)=CC=C1C(C=CC=C2)=C2CN3C([2H])([2H])C([2H])([2H])N(C4=CC=C(C=C4)C(NS(=O)(C5=CC([N+]([O-])=O)=C(C=C5)N[C@H](CCN(C)C)CSC6=CC=CC=C6)=O)=O)C([2H])([2H])C3([2H])[2H]
Molecular Formula
C42H37D8ClN6O5S2
Molecular Weight
821.48
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Ahamed Saleem, et al. Effect of dual inhibition of apoptosis and autophagy in prostate cancer. Prostate. 2012 Sep 1;72 (12) :1374-81.|[3]Clerc P, et al. Polster BM.Rapid Detection of an ABT-737-Sensitive Primed for Death State in Cells Using Microplate-Based Respirometry.PLoS One. 2012;7 (8) :e42487. Epub 2012 Aug 3.|[4]Konopleva M, et al. Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. Cancer Cell. 2006 Nov;10 (5) :375-88.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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