KY-455
KY-455 is a novel inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT) . KY-455 inhibita rabbit intestinal, hepatic, macrophage and adrenal ACAT with IC50 values of 0.4, 0.9, 2.9 and 4.1 μmol/L, respectively.
Product Specifications
CAS Number
178469-71-1
UNSPSC
12352005
Target
Acyltransferase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ky-455.html
Smiles
O=C(C(C)(C)C)NC1=C(C)C=C(C)C2=C1N(CCCCC)CC2
Molecular Formula
C20H32N2O
Molecular Weight
316.48
References & Citations
[1]Shohei Nakamura, et al. Hypolipidemic and antioxidant activity of the novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor KY-455 in rabbits and hamsters. Arzneimittelforschung. 2004;54 (2) :102-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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