KY-455

KY-455 is a novel inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT) . KY-455 inhibita rabbit intestinal, hepatic, macrophage and adrenal ACAT with IC50 values of 0.4, 0.9, 2.9 and 4.1 μmol/L, respectively.

Product Specifications

CAS Number

[178469-71-1]

UNSPSC

12352005

Target

Acyltransferase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/ky-455.html

Smiles

O=C(C(C)(C)C)NC1=C(C)C=C(C)C2=C1N(CCCCC)CC2

Molecular Formula

C20H32N2O

Molecular Weight

316.48

References & Citations

[1]Shohei Nakamura, et al. Hypolipidemic and antioxidant activity of the novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor KY-455 in rabbits and hamsters. Arzneimittelforschung. 2004;54 (2) :102-8.