Debutyldronedarone (hydrochloride)

Debutyldronedarone (SR35021) hydrochloride, the main metabolite of Dronedarone, is a selective thyroid hormone receptor α1 (TRα1) inhibitor. Debutyldronedarone hydrochloride inhibits T3 binding to TRα1 and TRβ1 by 77% and 25%, respectively. Debutyldronedarone hydrochloride can be used for the research of arrhythmic[1].

Product Specifications

CAS Number

[197431-02-0]

Product Name Alternative

SR35021 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Thyroid Hormone Receptor

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/debutyldronedarone-hydrochloride.html

Purity

98.73

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(C1=C(CCCC)OC2=C1C=C(NS(=O)(C)=O)C=C2)C3=CC=C(C=C3)OCCCNCCCC.Cl

Molecular Formula

C27H37ClN2O5S

Molecular Weight

537.11

Precautions

H302, H315, H319, H335

References & Citations

[1]Van Beeren HC, et al. Dronerarone acts as a selective inhibitor of 3,5,3'-triiodothyronine binding to thyroid hormone receptor-alpha1: in vitro and in vivo evidence. Endocrinology. 2003 Feb;144 (2) :552-8.