RGD peptide (GRGDNP)

RGD peptide (GRGDNP) is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) competitively inhibits α5β1 binding with extracellular matrice (ECM) . RGD peptide (GRGDNP) promotes apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) plays an important role in cell adhesion, migration, growth, and differentiation[1][2][3].

Product Specifications

CAS Number

[114681-65-1]

UNSPSC

12352209

Hazard Statement

H302, H315, H319

Target

Apoptosis; Caspase; Integrin

Type

Peptides

Related Pathways

Apoptosis; Cytoskeleton

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/rgd-peptide.html

Purity

99.83

Solubility

DMSO : 3.12 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

Smiles

O=C(O)[C@H]1N(C([C@H](CC(N)=O)NC([C@H](CC(O)=O)NC(CNC([C@H](CCCNC(N)=N)NC(CN)=O)=O)=O)=O)=O)CCC1

Molecular Formula

C23H38N10O10

Molecular Weight

614.61

Precautions

H302, H315, H319

References & Citations

[1]C D Buckley, et al. RGD peptides induce apoptosis by direct caspase-3 activation. Nature. 1999 Feb 11;397 (6719) :534-9.|[2]Wei Xia, et al. Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors. Nat Commun. 2021 Oct 15;12 (1) :6043.|[3]Akitoshi Sasamoto, et al. Mechanotransduction by integrin is essential for IL-6 secretion from endothelial cells in response to uniaxial continuous stretch. Am J Physiol Cell Physiol. 2005 May;288 (5) :C1012-22.