Avoralstat
Product Specifications
UNSPSC Description
Avoralstat (BCX4161), a potent and orally active plasma kallikrein (PKK) inhibitor, is used for hereditary angioedema research[1][2].
Target Antigen
Kallikrein
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/Avoralstat.html
Solubility
DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C(C1=NC(C(NCC2CC2)=O)=CC=C1C3=CC(OC)=C(C=C)C=C3C(NC4=CC=C(C(N)=N)C=C4)=O)O
Molecular Weight
513.54
References & Citations
[1]Aygoren-Pursun E, et al. Prophylaxis of hereditary angioedema attacks: A randomized trial of oral plasma kallikrein inhibition with avoralstat. J Allergy Clin Immunol. 2016 Sep;138(3):934-936.e5.|[2]Cornpropst M, et al. Safety, pharmacokinetics, and pharmacodynamics of avoralstat, an oral plasma kallikrein inhibitor: phase 1 study. Allergy. 2016;71(12):1676-1683.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-16735/Avoralstat-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-16735/Avoralstat-SDS-MedChemExpress.pdf
Clinical Information
Phase 3
CAS Number
918407-35-9
Available Sizes
Curated Selection
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