Avoralstat
Avoralstat (BCX4161), a potent and orally active plasma kallikrein (PKK) inhibitor, is used for hereditary angioedema research[1][2].
Product Specifications
CAS Number
918407-35-9
Product Name Alternative
BCX4161
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Kallikrein
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/Avoralstat.html
Concentration
10mM
Purity
98.0
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=NC(C(NCC2CC2)=O)=CC=C1C3=CC(OC)=C(C=C)C=C3C(NC4=CC=C(C(N)=N)C=C4)=O)O
Molecular Formula
C28H27N5O5
Molecular Weight
513.54
Precautions
H302, H315, H319, H335
References & Citations
[1]Aygoren-Pursun E, et al. Prophylaxis of hereditary angioedema attacks: A randomized trial of oral plasma kallikrein inhibition with avoralstat. J Allergy Clin Immunol. 2016 Sep;138 (3) :934-936.e5.|[2]Cornpropst M, et al. Safety, pharmacokinetics, and pharmacodynamics of avoralstat, an oral plasma kallikrein inhibitor: phase 1 study. Allergy. 2016;71 (12) :1676-1683.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
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