Avoralstat
Avoralstat (BCX4161), a potent and orally active plasma kallikrein (PKK) inhibitor, is used for hereditary angioedema research[1][2].
Product Specifications
CAS Number
[918407-35-9]
Product Name Alternative
BCX4161
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Kallikrein
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/Avoralstat.html
Concentration
10mM
Purity
98.0
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=NC(C(NCC2CC2)=O)=CC=C1C3=CC(OC)=C(C=C)C=C3C(NC4=CC=C(C(N)=N)C=C4)=O)O
Molecular Formula
C28H27N5O5
Molecular Weight
513.54
Precautions
H302, H315, H319, H335
References & Citations
[1]Aygoren-Pursun E, et al. Prophylaxis of hereditary angioedema attacks: A randomized trial of oral plasma kallikrein inhibition with avoralstat. J Allergy Clin Immunol. 2016 Sep;138 (3) :934-936.e5.|[2]Cornpropst M, et al. Safety, pharmacokinetics, and pharmacodynamics of avoralstat, an oral plasma kallikrein inhibitor: phase 1 study. Allergy. 2016;71 (12) :1676-1683.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6381039-01 0.1 mL
Hexosaminidase A (Hexosaminidase Subunit A, HEXA, Beta-hexosaminidase Subunit alpha, Beta-N-acetylhexosaminidase Subunit alpha, MGC99608, N-acetyl-beta-glucosaminidase Subunit alpha, TSD) (MaxLight 405)
Ask
View Details 
MBS6381039-02 5x 0.1 mL
Hexosaminidase A (Hexosaminidase Subunit A, HEXA, Beta-hexosaminidase Subunit alpha, Beta-N-acetylhexosaminidase Subunit alpha, MGC99608, N-acetyl-beta-glucosaminidase Subunit alpha, TSD) (MaxLight 405)
Ask
View Details 
QY-E01308 96 Tests
Human Carbon Catabolite Repression 4 Like Protein (CCRN4L) ELISA Kit
Ask
View Details MBS6459491-01 0.1 mL
Sqstm1 (Sequestosome-1, STONE14, Ubiquitin-Binding Protein p62, Sqstm1, A170, STAP) (MaxLight 550)
Ask
View Details MBS6459491-02 5x 0.1 mL
Sqstm1 (Sequestosome-1, STONE14, Ubiquitin-Binding Protein p62, Sqstm1, A170, STAP) (MaxLight 550)
Ask
View Details MBS7173410 Inquire
Rabbit anti-Escherichia coli O17:K52:H18 (strain UMN026/ExPEC) PRMA Polyclonal Antibody
Ask
View Details