16a-Hydroxydehydroisoandrosterone

16a-Hydroxydehydroisoandrosterone (16α-Hydroxy-DHEA) is a metabolite of the endogenous steroid hormone dehydroepiandrosterone. 16α-hydroxy Dehydroepiandrosterone is formed from dehydroepiandrosterone via 16-hydroxylation by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5 in adult human liver microsomes, as well as by fetal recombinant CYP3A7. It is a precursor to fetal estrogens, including estriol.

Product Specifications

CAS Number

[1232-73-1]

Product Name Alternative

16α-Hydroxy-DHEA; 16α-OH-DHEA; 16α-hydroxy DHEA

UNSPSC

12352211

Hazard Statement

H315-H319-H335

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/16a-hydroxydehydroisoandrosterone.html

Purity

98.40

Smiles

C[C@@]12[C@]3([H])[C@](CC=C1C[C@@H](O)CC2)([H])[C@@]4([H])[C@@](C)(C([C@H](O)C4)=O)CC3

Molecular Formula

C19H28O3

Molecular Weight

304.42

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]Miller, et al. Stereo- and regioselectivity account for the diversity of dehydroepiandrosterone (DHEA) metabolites produced by liver microsomal cytochromes P450. Drug. Metab. Dispos. 32 (3), 305-313 (2004) .