Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

BAM (8-22)

BAM (8-22), a proteolytically cleaved product of proenkephalin A and sensory neuron-specific receptor (SNSR) agonist, is a potent activator of Mas-related G-protein-coupled receptors (Mrgprs), MrgprC11 and hMrgprX1. BAM (8-22) induces scratching in mice in an Mrgpr-dependent manner. In addition, BAM (8-22) has an analgesic effect and can also inhibit the activation of microglia[1][2][3][4].

Product Specifications

CAS Number

412961-36-5

UNSPSC

12352209

Target

Mas-related G-protein-coupled Receptor (MRGPR)

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bam-8-22.html

Purity

99.86

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

OC(C=C1)=CC=C1C[C@@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(NCC(O)=O)=O)CC2=CC=C(C=C2)O)=O)=O)=O)=O)NC([C@H](CC(O)=O)NC([C@H](CCSC)NC([C@H](CC3=CNC4=CC=CC=C34)NC([C@@H](NC([C@H](CCC(O)=O)NC([C@H]5N(CCC5)C([C@H](CCCNC(N)=N)NC(CNC([C@@H](N)C(C)C)=O)=O)=O)=O)=O)CC6=CNC7=CC=CC=C67)=O)=O)=O)=O

Molecular Formula

C91H127N25O23S

Molecular Weight

1971.20

References & Citations

[1]Parul Sikand, et al. BAM8-22 peptide produces itch and nociceptive sensations in humans independent of histamine release. J Neurosci. 2011 May 18;31 (20) :7563-7.|[2]Liu Q, et al. Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus. Cell. 2009 Dec 24;139 (7) :1353-65.|[3]Wang A, et al. A Novel Mechanism of BAM8-22 Inhibiting Microglia Activation: Represses CX3CR1 Expression via Upregulating miR-184. J Mol Neurosci. 2020 Apr;70 (4) :550-558.|[4]Chen T, et al. Modulation of NMDA receptors by intrathecal administration of the sensory neuron-specific receptor agonist BAM8-22. Neuropharmacology. 2008 Apr;54 (5) :796-803.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

CD61 (ITGB3) Mouse Monoclonal Antibody [Clone ID: OTI5D9]
CF813972 100 µg

CD61 (ITGB3) Mouse Monoclonal Antibody [Clone ID: OTI5D9]

Sign In for Pricing
View Details
FGF12 (NM_004113) Human Recombinant Protein
TP720197M 50 µg

FGF12 (NM_004113) Human Recombinant Protein

Sign In for Pricing
View Details
Fucoidan (Technical Grade)
TRC-F836133-500MG 500 mg

Fucoidan (Technical Grade)

Sign In for Pricing
View Details
ALS (IGFALS) (NM_004970) Human Over-expression Lysate
LC401546 20 µg

ALS (IGFALS) (NM_004970) Human Over-expression Lysate

Sign In for Pricing
View Details
EGFR pTyr1110 Rabbit Polyclonal Antibody
AP02512PU-N 100 µL

EGFR pTyr1110 Rabbit Polyclonal Antibody

Sign In for Pricing
View Details
CD272 (BTLA) Mouse Monoclonal Antibody [Clone ID: OTI2H5]
CF812576 100 µg

CD272 (BTLA) Mouse Monoclonal Antibody [Clone ID: OTI2H5]

Sign In for Pricing
View Details