BAM (8-22)

BAM (8-22), a proteolytically cleaved product of proenkephalin A and sensory neuron-specific receptor (SNSR) agonist, is a potent activator of Mas-related G-protein-coupled receptors (Mrgprs), MrgprC11 and hMrgprX1. BAM (8-22) induces scratching in mice in an Mrgpr-dependent manner. In addition, BAM (8-22) has an analgesic effect and can also inhibit the activation of microglia[1][2][3][4].

Product Specifications

CAS Number

[412961-36-5]

UNSPSC

12352209

Target

Mas-related G-protein-coupled Receptor (MRGPR)

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bam-8-22.html

Purity

99.86

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

OC(C=C1)=CC=C1C[C@@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(NCC(O)=O)=O)CC2=CC=C(C=C2)O)=O)=O)=O)=O)NC([C@H](CC(O)=O)NC([C@H](CCSC)NC([C@H](CC3=CNC4=CC=CC=C34)NC([C@@H](NC([C@H](CCC(O)=O)NC([C@H]5N(CCC5)C([C@H](CCCNC(N)=N)NC(CNC([C@@H](N)C(C)C)=O)=O)=O)=O)=O)CC6=CNC7=CC=CC=C67)=O)=O)=O)=O

Molecular Formula

C91H127N25O23S

Molecular Weight

1971.20

References & Citations

[1]Parul Sikand, et al. BAM8-22 peptide produces itch and nociceptive sensations in humans independent of histamine release. J Neurosci. 2011 May 18;31 (20) :7563-7.|[2]Liu Q, et al. Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus. Cell. 2009 Dec 24;139 (7) :1353-65.|[3]Wang A, et al. A Novel Mechanism of BAM8-22 Inhibiting Microglia Activation: Represses CX3CR1 Expression via Upregulating miR-184. J Mol Neurosci. 2020 Apr;70 (4) :550-558.|[4]Chen T, et al. Modulation of NMDA receptors by intrathecal administration of the sensory neuron-specific receptor agonist BAM8-22. Neuropharmacology. 2008 Apr;54 (5) :796-803.