ISRIB
ISRIB is a brain-penetrant inhibitor of integrated stress response (ISR) . Persistent activation of the ISR has been linked to the development of several neurological disorders as ISR represses translation through inhibiting eIF2B. ISRIB inhibits the ISR by promoting the nucleotide exchange activity of eIF2B and recovering the translation, and thus can be used for neurological disorders research[1][2][3].
Product Specifications
CAS Number
548470-11-7
UNSPSC
12352200
Hazard Statement
H302, H315, H319, H335
Target
Biochemical Assay Reagents; Eukaryotic Initiation Factor (eIF)
Type
Biochemical Assay Reagents
Related Pathways
Cell Cycle/DNA Damage; Others
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/isrib.html
Purity
98.58
Solubility
DMSO : 6.25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NC1CCC(NC(COC2=CC=C(Cl)C=C2)=O)CC1)COC3=CC=C(Cl)C=C3
Molecular Formula
C22H24Cl2N2O4
Molecular Weight
451.34
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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