ISRIB

ISRIB is a brain-penetrant inhibitor of integrated stress response (ISR) . Persistent activation of the ISR has been linked to the development of several neurological disorders as ISR represses translation through inhibiting eIF2B. ISRIB inhibits the ISR by promoting the nucleotide exchange activity of eIF2B and recovering the translation, and thus can be used for neurological disorders research[1][2][3].

Product Specifications

CAS Number

[548470-11-7]

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Biochemical Assay Reagents; Eukaryotic Initiation Factor (eIF)

Type

Biochemical Assay Reagents

Related Pathways

Cell Cycle/DNA Damage; Others

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/isrib.html

Purity

98.58

Solubility

DMSO : 6.25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NC1CCC(NC(COC2=CC=C(Cl)C=C2)=O)CC1)COC3=CC=C(Cl)C=C3

Molecular Formula

C22H24Cl2N2O4

Molecular Weight

451.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Zyryanova AF, et al. ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B. Mol Cell. 2021 Jan 7;81 (1) :88-103.e6.|[2]Halliday M, et al. Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity. Cell Death Dis. 2015 Mar 5;6 (3) :e1672.|[3]Sidrauski C, et al. The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly. Elife. 2015 Feb 26;4:e05033.