GSK2837808A
GSK2837808A is a potent and selective lactate dehydrogenase A (LDHA) inhibitor with IC50s of 2.6 and 43 nM for hLDHA and hLDHB, respectively.
Product Specifications
CAS Number
[1445879-21-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Lactate Dehydrogenase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/GSK2837808A.html
Purity
99.24
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(O)C1=CC(OC2=CC(F)=CC(F)=C2)=CC(NC3=C(S(=O)(NC4CC4)=O)C=NC5=CC(C6=CN=C(OC)N=C6OC)=CC=C35)=C1
Molecular Formula
C31H25F2N5O7S
Molecular Weight
649.62
Precautions
H302, H315, H319, H335
References & Citations
[1]Billiard J, et al. Quinoline 3-sulfonamides inhibit lactate dehydrogenase A and reverse aerobic glycolysis in cancer cells. Cancer Metab. 2013 Sep 6;1 (1) :19.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
LDHA; LDHB
Available Sizes
Curated Selection
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