DIDS (sodium salt)

DIDS sodium salt (MDL101114ZA) is a dual inhibitor of ABCA1 and VDAC1. DIDS also inhibits RAD51, inhibiting RAD51-mediated homologous pairing and strand exchange reactions. DIDS inhibits anion exchange and binding to red blood cell membranes, inhibits the activation of caspase-3 and -9, and can be used in cancer research[1][2][3][4].

Product Specifications

CAS Number

[67483-13-0]

Product Name Alternative

MDL101114ZA

UNSPSC

12171500

Hazard Statement

H315, H317, H319, H330, H334, H335, H351, H412

Target

RAD51; VDAC

Type

Dye Reagents

Related Pathways

Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/DIDS_sodium_salt.html

Purity

99.13

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=S(C1=CC(N=C=S)=CC=C1/C=C/C2=CC=C(N=C=S)C=C2S(=O)(O[Na])=O)(O[Na])=O

Molecular Formula

C16H8N2Na2O6S4

Molecular Weight

498.48

Precautions

H315, H317, H319, H330, H334, H335, H351, H412

References & Citations

[1]Tsou CY, et al. Activation of soluble guanylyl cyclase prevents foam cell formation and atherosclerosis. Acta Physiol (Oxf) . 2014 Apr;210 (4) :799-810.|[2]Chen H, et al. Inhibition of VDAC1 prevents Ca²⁺-mediated oxidative stress and apoptosis induced by 5-aminolevulinic acid mediated sonodynamic therapy in THP-1 macrophages. Apoptosis. 2014 Dec;19 (12) :1712-26.