α-Conotoxin Im-I
Product Specifications
UNSPSC Description
α-Conotoxin Im-I is a selective α7/α9 nAChR antagonist, blocking α7 nicotinic receptors with the highest apparent affinity, while having an 8-fold lower affinity for homomeric α9 nicotinic receptors. α-Conotoxin Im-I is toxic and induces seizures in rodents. α-Conotoxin Im-I is a tool for studying neuronal nAChR[1][2].
Target Antigen
nAChR
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Purity
98.15
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C(C=1C=2C(NC1)=CC=CC2)[C@H]3C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(N)=O)CSSC[C@@]4(NC(=O)[C@@H](NC(CN)=O)CSSC[C@@](C(=O)N[C@@H](C)C(=O)N3)(NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@]5(N(C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC4=O)CCC5)[H])[H])[H]
Molecular Weight
1351.56
References & Citations
[1]Johnson DS, et al. alpha-Conotoxin ImI exhibits subtype-specific nicotinic acetylcholine receptor blockade: preferential inhibition of homomeric alpha 7 and alpha 9 receptors. |[2]Quiram P A, et al. Pairwise interactions between neuronal α7acetylcholine receptors and α-conotoxin PnIB. Journal of Biological Chemistry, 2000, 275(7): 4889-4896.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Clinical Information
No Development Reported
CAS Number
156467-85-5
Available Sizes
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