α-Conotoxin Im-I

α-Conotoxin Im-I is a selective α7/α9 nAChR antagonist, blocking α7 nicotinic receptors with the highest apparent affinity, while having an 8-fold lower affinity for homomeric α9 nicotinic receptors. α-Conotoxin Im-I is toxic and induces seizures in rodents. α-Conotoxin Im-I is a tool for studying neuronal nAChR[1][2].

C(C=1C=2C(NC1)=CC=CC2)[C@H]3C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(N)=O)CSSC[C@@]4(NC(=O)[C@@H](NC(CN)=O)CSSC[C@@](C(=O)N[C@@H](C)C(=O)N3)(NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@]5(N(C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC4=O)CCC5)[H])[H])[H]

[1]Johnson DS, et al. alpha-Conotoxin ImI exhibits subtype-specific nicotinic acetylcholine receptor blockade: preferential inhibition of homomeric alpha 7 and alpha 9 receptors. |[2]Quiram P A, et al. Pairwise interactions between neuronal α7acetylcholine receptors and α-conotoxin PnIB. Journal of Biological Chemistry, 2000, 275(7): 4889-4896.